Detalles de la búsqueda
1.
Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection.
Gut
; 72(7): 1385-1398, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36697207
2.
JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection.
Gastroenterology
; 159(2): 521-533.e9, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32343960
3.
Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
J Viral Hepat
; 27(11): 1127-1137, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32579776
4.
Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30181376
5.
Dose proportionality and pharmacokinetics of extended-release (OROS®) hydromorphone: a phase 1, open-label, randomized, crossover study in healthy Taiwanese subjects.
Int J Clin Pharmacol Ther
; 52(3): 217-26, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24472398
6.
Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study.
Antiviral Res
; 216: 105660, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37385475
7.
Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants.
Antivir Ther
; 28(1): 13596535231151626, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36691849
8.
A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults.
Antivir Ther
; 28(3): 13596535231172878, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37199270
9.
Drug-Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379 (Bersacapavir).
Clin Pharmacol Drug Dev
; 11(12): 1419-1429, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36062869
10.
A quantitative systems pharmacology model for acute viral hepatitis B.
Comput Struct Biotechnol J
; 19: 4997-5007, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34589180
11.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.
Antivir Ther
; 26(3-5): 58-68, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35485332
12.
Correction to: Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects.
Adv Ther
; 37(4): 1703, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-32133584
13.
Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects.
Adv Ther
; 36(9): 2450-2462, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31267367
14.
Immune network for viral hepatitis B: Topological representation.
Eur J Pharm Sci
; 136: 104939, 2019 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31195071
15.
Safety, Tolerability, and Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Multiple-Ascending-Dose Study.
Clin Pharmacol Drug Dev
; 6(6): 592-603, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28881493
16.
Single-Dose Pharmacokinetic Study of Tramadol Extended-Release Tablets in Children and Adolescents.
Clin Pharmacol Drug Dev
; 5(5): 343-53, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27138295
17.
The effect of UGT2B7*2 polymorphism on the pharmacokinetics of OROS® hydromorphone in Taiwanese subjects.
J Clin Pharmacol
; 54(10): 1170-9, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24706503
18.
Complementary pharmacokinetic measures to further define the profile of once-daily OROS hydromorphone ER during single-dose and steady-state dosing.
Springerplus
; 2: 625, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24349945
19.
Repeat-dose steady-state pharmacokinetic evaluation of once-daily hydromorphone extended-release (OROS(®) hydromorphone ER) in patients with chronic pain.
J Pain Res
; 5: 523-33, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23166450
20.
Randomized 5-treatment crossover study to assess the effects of external heat on serum fentanyl concentrations during treatment with transdermal fentanyl systems.
J Clin Pharmacol
; 52(8): 1174-85, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21878578